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Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
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Novel HLA allele, HLA-B*4013, identified from a potential bone marrow recipient. Putative gene conversion events with

P V Blanco1, G Theile, C Marcos

  • 1Laboratorio de Inmunogenética, Hospital de Clínicas, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina.

Tissue Antigens
|May 31, 2001
PubMed

A new B40 allele was identified in a leukemic Caucasian patient. This allele, designated B*4013, differs in alpha 1 domain from B*4002 at six amino acidic positions: 67, 77, 80, 81, 82 and 83. Most of this substitutions could alter the antigen binding site of the HLA-B molecule. B*4013 may have originated by gene conversion or reciprocal recombination involving B*4002 as the recipient allele of sequence donated by B*4406. The new allele was serologically typed as a "blank" associated with the Bw4 epitope.

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