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Related Experiment Videos

Placebo response, placebo effect, and two attributes.

D M McNair, G Gardos, D S Haskell

    Psychopharmacology
    |June 21, 1979
    PubMed
    Summary
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    This study explored predictors of placebo response in psychiatric patients. Acquiescence predicted placebo effects, while autonomic awareness indicated general improvement, not specific placebo response.

    Area of Science:

    • Psychiatry
    • Psychology
    • Clinical Research

    Background:

    • Understanding placebo response is crucial in psychiatric treatment.
    • Identifying predictors can optimize therapeutic outcomes.
    • Previous research suggested potential correlates of placebo effects.

    Purpose of the Study:

    • To investigate two putative predictors of placebo response in psychiatric outpatients.
    • To differentiate between true placebo effects and nonspecific treatment improvements.
    • To examine the relationship between acquiescence and autonomic awareness with treatment outcomes.

    Main Methods:

    • Three samples of psychiatric outpatients were studied.
    • Two groups received placebo treatment for one week.
    • A quasi-control group received no medication before psychotherapy.

    Related Experiment Videos

    Main Results:

    • Acquiescence (traditionalism) predicted placebo response, replicating prior findings.
    • Acquiescence was not related to change in the control group, suggesting a potential correlate of true placebo effect.
    • Autonomic awareness was associated with change across all samples, indicating nonspecific improvement likely linked to somatization intensity.

    Conclusions:

    • Acquiescence may be a specific predictor of placebo response in certain conditions.
    • Autonomic awareness appears to predict general, rather than specific, treatment improvement.
    • Further research is needed to clarify the generality and mechanisms of these predictors.