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Familial microscopic colitis.

A A Abdo1, P J Zetler, L S Halparin

  • 1University of British Columbia, Vancouver, Canada.

Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie
|May 31, 2001
PubMed
Summary

This report details a rare familial case of microscopic colitis, where a mother and daughter were diagnosed with different forms of the condition. This suggests a potential genetic link and shared disease process for collagenous and lymphocytic colitis.

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Area of Science:

  • Gastroenterology
  • Genetics
  • Immunology

Background:

  • Microscopic colitis encompasses collagenous colitis and lymphocytic colitis, both inflammatory colon conditions.
  • Familial occurrences of these conditions are rare, with only two prior reports in literature.

Observation:

  • A 55-year-old woman with chronic diarrhea was diagnosed with lymphocytic colitis.
  • Her 36-year-old daughter was subsequently diagnosed with collagenous colitis.

Findings:

  • This case represents the third reported instance of familial microscopic colitis.
  • The familial pattern supports an immunological etiology and suggests collagenous and lymphocytic colitis may be manifestations of a single disease process.

Implications:

  • The familial tendency highlights the potential for a genetic predisposition to microscopic colitis.
  • Early colonoscopy and biopsy in symptomatic relatives of diagnosed patients may be warranted.

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