Inhaled corticosteroids as first-line therapy for asthma. Why they work--and what the guidelines and evidence suggest

Despite a plethora of clinical guidelines and evidence outlining the efficacy of inhaled corticosteroids, these medications continue to be underused in the treatment of asthma. This article reviews the justification for prescribing inhaled steroids as first-line therapy, discusses indications for their use, and compares potencies of the various products now available. In addition, the authors address the adverse effects commonly associated with these agents and provide evidence supporting early intervention with inhaled steroids in the treatment of persistent asthma.