Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Systemic inflammatory response syndrome: new concepts].

R Carrillo-Esper1, F N Núñez-Monroy

  • 1Servicio Unidad de Terapia Intensiva, Hospital Central Sur, Petróleos Mexicanos, México D.F.

Gaceta Medica De Mexico
|May 31, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Type B right ventricle thrombus in transit].

Gaceta medica de Mexico·2001
Same author

[Mount Fuji sign].

Gaceta medica de Mexico·2000
Same author

[Hemophilic pseudotumor in pediatric patient].

Gaceta medica de Mexico·2000
Same author

[The acute respiratory insufficiency syndrome].

Gaceta medica de Mexico·1999
Same author

[Inhaled nitric oxide: one modality in the treatment of ARDS].

Gaceta medica de Mexico·1999
Same author

[A tumor in the anterior mediastinum (thymoma) in a young woman of 20].

Gaceta medica de Mexico·1999

Systemic inflammatory response syndrome (SIRS) involves complex inflammatory and anti-inflammatory processes. Gamma interferon and steroids show promise in managing immune paralysis and dissonance phases of SIRS.

Area of Science:

  • Immunology
  • Pathophysiology

Context:

  • Systemic inflammatory response syndrome (SIRS) arises from various injuries, aiming to limit damage.
  • The intensity of SIRS depends on injury severity and the balance between inflammatory and anti-inflammatory responses.

Purpose:

  • To explore the phases of inflammatory and anti-inflammatory responses in SIRS.
  • To investigate the potential of gamma interferon and steroids in modulating SIRS progression.

Summary:

  • SIRS evolves through distinct phases: local, systemic, massive systemic, immunologic paralysis, and immune dissonance.
  • Uncontrolled progression, particularly the latter three phases, can amplify cell damage, leading to multiple organ dysfunction.
  • Gamma interferon and steroids are being studied for their immunomodulatory effects in the paralysis and dissonance stages of SIRS.

Related Experiment Videos

Impact:

  • Understanding SIRS phases is crucial for managing critical illness.
  • Gamma interferon and steroids may offer therapeutic strategies for severe SIRS, potentially improving patient outcomes.
  • Further clinical validation is required to establish the efficacy of these immunomodulators.