Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cyclolinopeptides F-I, cyclic peptides from linseed.

T Matsumoto1, A Shishido, H Morita

  • 1School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Japan.

Phytochemistry
|May 31, 2001
PubMed
Summary

Four new cyclolinopeptides (F-I) from Linum usitatissimum seeds show immunosuppressive activity. Researchers elucidated their structures using NMR spectroscopy and chemical degradation, confirming their biological potential.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical intraocular islet transplantation is not a number issue.

CellR4-- repair, replacement, regeneration, & reprogramming·2018
Same author

Thermo-, photo-, and mechano-responsive liquid crystal networks enable tunable photonic crystals.

Soft matter·2017
Same author

Design and operating experiences of full-scale municipal membrane bioreactors in Japan.

Water science and technology : a journal of the International Association on Water Pollution Research·2014
Same author

Role of T cell recruitment and chemokine-regulated intra-graft T cell motility patterns in corneal allograft rejection.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2013
Same author

Design and operating experiences of municipal MBRs in Europe.

Water science and technology : a journal of the International Association on Water Pollution Research·2008
Same author

Comparison of 40 and 60 milliliters of contrast in assessment of the carotid artery by computed tomography angiography.

Acta radiologica (Stockholm, Sweden : 1987)·2008

Area of Science:

  • Natural Product Chemistry
  • Immunology
  • Organic Chemistry

Background:

  • Linum usitatissimum (flaxseed) is a source of bioactive compounds.
  • Cyclic peptides possess diverse biological activities.
  • Understanding the chemical structures of natural products is key to their application.

Purpose of the Study:

  • To isolate and characterize novel cyclic peptides from Linum usitatissimum seeds.
  • To elucidate the chemical structures of these isolated compounds.
  • To evaluate the immunosuppressive potential of the identified cyclolinopeptides.

Main Methods:

  • Isolation of cyclic peptides using chromatographic techniques.
  • Structure elucidation via extensive 2D Nuclear Magnetic Resonance (NMR) spectroscopy.

Related Experiment Videos

  • Chemical degradation studies to confirm structural assignments.

    • Main Results:

    • Four cyclic peptides, designated cyclolinopeptides F-I, were successfully isolated.
    • The complete structures of cyclolinopeptides F-I were determined.
    • Preliminary examination indicated immunosuppressive activity for these compounds.

    Conclusions:

    • Linum usitatissimum seeds contain structurally novel cyclolinopeptides.
    • The elucidated structures provide a basis for further pharmacological investigation.
    • Cyclolinopeptides F-I represent a potential new class of immunosuppressive agents.