Treatment of conjunctival and corneal intraepithelial neoplasia with topical interferon alpha-2b
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Updated: Oct 7, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
C L Karp1, J K Moore, R H Rosa
1Bascom Palmer Eye Institute, University of Miami, Miami, Florida 33136, USA.
Objective:
To evaluate the role of topical interferon alfa-2b (IFNalpha2b) in the treatment of conjunctival and corneal intraepithelial neoplasia (CIN).
Design:
Noncomparative case series.
Participants:
Five patients with histologically proven CIN or recurrences of proven CIN were studied prospectively.
Intervention:
After histologic confirmation, patients were given topical recombinant IFNalpha2b (INTRON A, Schering Plough, Kenilworth, NJ) 1 million IU/ml four times a day. Patients were continued on interferon until complete resolution of the tumor had occurred.
Main Outcome Measures:
Patients were followed clinically and photographically for evidence of tumor resolution.
Results:
All patients had complete resolution of the CIN lesion on IFNalpha2b. The mean time to clinical resolution was 11.6 weeks (range, 4-22 weeks). The mean follow-up was 17.6 months (range, 7-28 months). One patient had a clinical recurrence of his corneal CIN 1 year after tumor resolution. This patient was retreated, resulting in clinical resolution within 6 weeks, and has been tumor free for 8 months of follow-up.
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