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Midtrimester pregnancy interruption and the placental progesterone levels
Prostaglandins
|March 1, 1975
Abstract:
Placental progesterone contents were studied in 10 patients therapeutically aborted at midtrimester by intraamniotic infusions of hypertonic saline, and from 14 patients (12-20 weeks) aborted by intraamniotic instillation of prostaglandin F-2alpha. The mean S.E. of the progesterone was 1.99 plus or minus 0.07 ug/g. placental tissue in the first group, while with prostaglandin abortion the placental progesterone was 1.45 plus or minus 0.08 ug/g. tissue, which is significantly lower than the results in the first group (P equals 0.001). The possible mechanism of action of prostaglandin as an effective abortifacient is discussed.
Keywords:
Abortifacient AgentsAbortion, Drug InducedAbortion, InducedBiologyComparative StudiesEmbryoEndocrine SystemFamily PlanningFertility Control, PostconceptionFetal MembranesFetusHormonesIngredients And ChemicalsMaternal-fetal ExchangePhysiologyPregnancyPregnancy, Second TrimesterProgestational HormonesProgesterone--analysisProstaglandins--administraction and dosageReproductionResearch MethodologySaline Solution, Hypertonic--administraction and dosageStudies