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[Myasthenia gravis and sleep].

R Stepansky1, J Zeitlhofer

  • 1Universitätsklinik für Neurologie, Wien, Osterreich.

Wiener Klinische Wochenschrift
|June 1, 2001
PubMed
Summary

Nocturnal respiratory dysfunction during REM sleep is common in myasthenia gravis but often undiagnosed. Polysomnography can detect sleep-related breathing disorders, aiding diagnosis in patients with potential central nervous system involvement.

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Sleep spindle-related activity in the human EEG and its relation to general cognitive and learning abilities.

The European journal of neuroscience·2006

Area of Science:

  • Neurology
  • Sleep Medicine
  • Respiratory Medicine

Context:

  • Myasthenia gravis (MG) frequently involves nocturnal respiratory disturbances, particularly during REM sleep, despite normal daytime function.
  • These nocturnal respiratory issues are often undiagnosed, leading to potential complications.
  • Symptoms like sleepiness, and cognitive deficits may indicate underlying sleep-related breathing disorders in MG patients.

Purpose:

  • To highlight the significance of nocturnal respiratory function in myasthenia gravis.
  • To propose sleep-related breathing disorders as a potential cause for central nervous system symptoms in MG.
  • To advocate for polysomnography in diagnosing sleep disorders in MG patients with neurological symptoms.

Summary:

  • Nocturnal respiratory function is often impaired during REM sleep in myasthenia gravis, even with normal daytime breathing.
  • Sleepiness and cognitive problems in MG patients may stem from sleep-related breathing disorders.
  • Central nervous system involvement in MG, possibly due to acetylcholine receptor antibodies or hypoxia, can affect REM sleep and cognition.

Impact:

  • Emphasizes the need for diagnosing nocturnal respiratory problems in myasthenia gravis.
  • Suggests polysomnography as a crucial diagnostic tool for MG patients with CNS symptoms.
  • Improves understanding of the interplay between sleep, respiration, and neurological function in myasthenia gravis.

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