A safety-catch linker for amine release under biologically compatible conditions
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Updated: Oct 7, 2026

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Solid Phase Synthesis of a Functionalized Bis-Peptide Using "Safety Catch" Methodology
Published on: May 15, 2012
Molecular Diversity
|June 1, 2001
Abstract:
A 'biocompatible' safety-catch linker based on an internal diketopiperazine release has been developed to allow the release of amine based compounds. The synthesis of the linker and its pre-loading with a representative set of amines is described. After immobilization onto an amino Tentagel resin, the linker was activated and the amines were released under biological conditions at pH 8.
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