Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

False-negative breast screening assessment: what lessons can we learn?

H C Burrell1, A J Evans, A R Wilson

  • 1Nottingham Breast Screening Unit, City Hospital NHS Trust, Nottingham NG5 1PG, U.K.

Clinical Radiology
|June 1, 2001
PubMed
Summary

False-negative mammogram assessments occurred in 0.56% of cases, with micro-calcifications being the most common cause. Prompt biopsy of suspicious micro-calcifications is crucial for accurate breast cancer diagnosis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Histology of Convergent Probing Appendages in Mormyridae.

Integrative organismal biology (Oxford, England)·2023
Same author

Reply by Authors.

The Journal of urology·2020
Same author

What Can We Learn from Parents of Caries-Free and Caries-Active Hispanic Children?

JDR clinical and translational research·2020
Same author

Randomized Trial of Motivational Interviewing to Prevent Early Childhood Caries in American Indian Children.

JDR clinical and translational research·2018
Same author

Maternal Factors Associated with Early Childhood Caries in Urban Latino Children.

JDR clinical and translational research·2017
Same author

Distinguishing globally-driven changes from regional- and local-scale impacts: The case for long-term and broad-scale studies of recovery from pollution.

Marine pollution bulletin·2017

Area of Science:

  • Radiology
  • Oncology
  • Medical Imaging

Background:

  • Mammography is a key tool for early breast cancer detection.
  • False-negative assessments can delay diagnosis and treatment.
  • Understanding the characteristics of false-negative findings is essential for improving screening accuracy.

Purpose of the Study:

  • To determine the frequency and characteristics of false-negative mammographic assessments in women diagnosed with breast cancer after initial screening.
  • To identify specific mammographic findings associated with false-negative interpretations.

Main Methods:

  • Retrospective review of 28 women with breast cancer diagnosed after a previous negative mammogram assessment.
  • Analysis of mammographic, clinical, and ultrasound findings.

Related Experiment Videos

  • Review of fine needle aspiration cytology and needle histology results.

    • Main Results:

    • The frequency of false-negative assessment was approximately 0.56%.
    • The median time to diagnosis after a false-negative assessment was 33 months.
    • Micro-calcifications were the most common mammographic abnormality (43%) leading to false-negative assessments, often misinterpreted as benign.

    Conclusions:

    • Radiological interpretation of micro-calcifications is unreliable; image-guided core biopsy is recommended.
    • Architectural distortions on mammography require careful reassessment.
    • Discrepancies between imaging modalities should be managed based on the most abnormal finding.