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Updated: Jul 28, 2026

Detection of Infectious Virus from Field-collected Mosquitoes by Vero Cell Culture Assay
Published on: June 9, 2011
The first reported case of California encephalitis in more than 50 years
B F Eldridge1, C Glaser, R E Pedrin
1University of California, Davis, California 95616, USA. bfeldridge@ucdavis.edu
Abstract:
A recent case of California encephalitis, a rare mosquito-borne viral disease, represents only the fourth ever reported and the first since the initial three cases in 1945. This case was diagnosed retrospectively on the basis of a rise in antibody titer between acute- and convalescent-phase serum samples.
Insights
A rare California encephalitis case, a mosquito-borne virus, was recently identified. This marks the fourth reported instance of this rare viral disease, with the first three cases documented in 1945.
Area of Science:
- Arbovirology
- Infectious Diseases
- Public Health
Background:
- California encephalitis is a rare mosquito-borne viral disease.
- The disease has had very few documented cases historically.
Observation:
- A recent case of California encephalitis was diagnosed retrospectively.
- Diagnosis was confirmed by a rise in antibody titer between acute- and convalescent-phase serum samples.
Findings:
- This represents the fourth reported case of California encephalitis globally.
- It is the first case reported since the initial three cases in 1945.
Implications:
- This finding highlights the continued, albeit rare, circulation of California encephalitis virus.
- Further surveillance may be warranted to understand the epidemiology of this rare arbovirus.
- This case underscores the importance of diagnostic capabilities for rare vector-borne diseases.
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