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Updated: Oct 7, 2026
Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
Published on: December 2, 2022
Absence of type I estrogen receptors in choroidal melanoma: analysis of Collaborative Ocular Melanoma Study (COMS)
R J Grostern1, I Slusker Shternfeld, S S Bacus
1Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, 53792, USA.
Purpose:
To evaluate choroidal melanomas in enucleated eyes for the presence of type I estrogen receptors.
Methods:
Fourteen consecutive eyes with large choroidal melanomas (defined as >16-mm basal diameter and >8 mm thickness) from 14 patients (eight women and six men with a mean age of 57 years; range, 25--74 years) enucleated in accordance with the Collaborative Ocular Melanoma Study (COMS) protocol were investigated. Immunohistochemical techniques were employed to label the choroidal melanomas for the presence of type I estrogen receptors. Each specimen was then evaluated in a masked fashion by an experienced ophthalmic pathologist for positive nuclear staining.
Results:
No tumors showed immunohistochemical evidence of a type I estrogen receptor.
Conclusion:
Type I estrogen receptors are not present in choroidal melanoma. Estrogens are not likely to influence choroidal melanoma growth through traditional receptors.
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