Chromosomal translocation 3;22 in an infertile man
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Updated: Aug 1, 2026

FISH for Pre-implantation Genetic Diagnosis
Published on: February 23, 2011
J L Quintana de la Rosa1, G Gallegos Avila, R García Cavazos
1Department of Urology, POVISA Medical Center, Vigo, Spain. jlrq@yahoo.com
Objective:
To present the first case of an infertile male with a normal phenotype and chromosomal translocation 3;22.
Design:
Case report.
Setting:
POVISA Medical Center.
Patient(S):
A 45-year-old man with primary infertility for 13 years and with different partners; the patient has a family history of recurrent miscarriages and low fertility.
Intervention(S):
Lymphocytic karyotype and electron microscopy.
Main Outcome Measure(S):
Physical examination and semen analysis.
Result(S):
The semen analysis revealed oligoasthenoteratospermia. The lymphocytic karyotype detected a translocation 3;22, and electron microscopy showed a lack of the central microtubule pair and peripheral doublet.
Conclusion(S):
An association between translocation 3;22 and other abnormalities in infertile males has been reported, but no such association has ever been described in men whose only clinical manifestation is infertility.
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