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Related Experiment Videos

Marfan's syndrome and multiple extracranial aneurysms.

R Sztajzel1, S Hefft, C Girardet

  • 1Department of Neurology, University Hospital Geneva, Switzerland. Roman.Sztajzel@hcgeu.ch

Cerebrovascular Diseases (Basel, Switzerland)
|June 1, 2001
PubMed
Summary

Marfan syndrome can cause rare, isolated aneurysms in neck arteries. This case highlights transient ischemic attacks (TIAs) linked to vertebral and carotid artery aneurysms in Marfan syndrome patients.

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Area of Science:

  • Vascular Surgery
  • Neurology
  • Genetics

Background:

  • Marfan syndrome is a genetic disorder affecting connective tissue, predisposing individuals to aortic and arterial aneurysms.
  • Extracranial cervical artery aneurysms in Marfan syndrome are typically extensions of aortic dissections.
  • Isolated, spontaneous aneurysms of extracranial arteries are rare in Marfan syndrome and usually asymptomatic.

Observation:

  • A patient with Marfan syndrome presented with symptoms of transient ischemic attacks (TIAs).
  • Diagnostic imaging revealed a saccular aneurysm of the vertebral artery.
  • Bilateral fusiform aneurysms of the internal carotid arteries were also identified.

Findings:

  • This case reports the first instance of transient ischemic attacks (TIAs) associated with isolated extracranial arterial aneurysms in a patient with Marfan syndrome.

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  • The findings include multiple aneurysms: one saccular vertebral artery aneurysm and bilateral fusiform internal carotid artery aneurysms.
  • This presentation challenges the notion that isolated extracranial aneurysms in Marfan syndrome are invariably asymptomatic.

    • Implications:

    • The study suggests a potential link between isolated extracranial arterial aneurysms and neurological events like TIAs in Marfan syndrome patients.
    • Early detection and monitoring of extracranial arterial aneurysms may be crucial in managing Marfan syndrome.
    • Further research is warranted to understand the pathogenesis and clinical significance of these rare arterial manifestations in Marfan syndrome.