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Related Experiment Videos

Left ventricular ejection fraction in severe chronic obstructive airways disease.

P Steele, J H Ellis, D Van Dyke

    The American Journal of Medicine
    |July 1, 1975
    PubMed
    Summary

    Left ventricular ejection fraction (LVEF) is typically normal in severe chronic obstructive airways disease (COPD) patients without coronary artery disease. Reduced LVEF in COPD patients is likely due to coexisting coronary artery disease, not lung disease alone.

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    Area of Science:

    • Cardiology
    • Pulmonology
    • Internal Medicine

    Background:

    • The relationship between chronic obstructive airways disease (COPD) and left ventricular function remains a subject of debate.
    • Assessing left ventricular ejection fraction (LVEF) is crucial for understanding cardiac health in patients with respiratory conditions.

    Purpose of the Study:

    • To investigate left ventricular ejection fraction (LVEF) in patients with severe chronic obstructive airways disease (COPD).
    • To determine if COPD itself or coexisting coronary artery disease (CAD) affects LVEF.

    Main Methods:

    • Measured LVEF using a bedside radionuclide technique with a scintillation probe in 120 severe COPD patients (92 acute, 28 stable).
    • Assessed for the presence of coronary artery disease (CAD) clinically or via autopsy.

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  • Correlated LVEF with the presence of CAD and with arterial blood gas parameters (oxygen, carbon dioxide, pH).

    • Main Results:

    • In acutely decompensated COPD patients, 60% had normal LVEF (≥55%) and 32% had subnormal LVEF.
    • In stable COPD patients, 12 had normal LVEF and 16 had low LVEF.
    • Significantly lower LVEF was observed in COPD patients with CAD (acute: 28±10.4%, stable: 42±3.5%) compared to those without CAD (acute: 61±1.9%, stable: 55±2.1%).
    • No correlation was found between LVEF and arterial oxygen, carbon dioxide tension, or pH.

    Conclusions:

    • Severe chronic obstructive airways disease (COPD) alone does not appear to impair left ventricular ejection fraction (LVEF).
    • Reduced LVEF in patients with COPD is strongly associated with the presence of coronary artery disease (CAD).
    • Clinical evaluation for CAD is essential in COPD patients presenting with diminished LVEF.