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Related Concept Videos

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Cells of the Adaptive Immune Response01:23

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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Antigens Involved in Adaptive Immunity01:26

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An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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Cytotoxic T Cells-mediated Immune Response01:27

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
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Tumor Immunotherapy01:27

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Related Experiment Video

Updated: May 5, 2026

Generation of Orthotopic Pancreatic Tumors and Ex vivo Characterization of Tumor-Infiltrating T Cell Cytotoxicity
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Generation of Orthotopic Pancreatic Tumors and Ex vivo Characterization of Tumor-Infiltrating T Cell Cytotoxicity

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The allogeneic response and tumor immunity.

J W Fabre1

  • 1Department of Clinical Sciences, Institute of Liver Studies Guy's, King's and St Thomas' School of Medicine, London, UK. john.fabre@kcl.ac.uk

Nature Medicine
|June 1, 2001
PubMed
Summary

Harnessing the immune system

Area of Science:

  • Immunology
  • Transplantation Immunology
  • Cancer Immunology

Background:

  • The immune system mounts a strong response to foreign donor molecules (MHC) during transplantation.
  • Conversely, the immune response to cancer antigens is often weak.
  • These distinct immune responses may interact and be leveraged for therapeutic benefit.

Purpose of the Study:

  • To explore the potential of utilizing the strong allogeneic immune response to enhance anti-tumor immunity.
  • To investigate how T-cell responses to donor MHC molecules could be redirected against cancer.

Main Methods:

  • Review and discussion of existing immunological principles.
  • Analysis of potential mechanisms for immune cross-reactivity.
  • Exploration of therapeutic strategies in cancer immunotherapy.

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Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
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Main Results:

  • Allogeneic responses can potentially prime T-cells for recognizing tumor antigens.
  • This immune cross-reactivity could overcome the typical weak anti-tumor response.
  • Harnessing allogeneic responses may offer a novel approach to cancer treatment.

Conclusions:

  • The strong immune response to donor MHC molecules presents a unique opportunity.
  • Redirecting this response could lead to effective immune eradication of metastatic cancer.
  • This strategy holds promise for advancing cancer immunotherapy.