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BPH with coexisting overactive bladder dysfunction--an everyday urological dilemma.

T Knutson1, C Edlund, M Fall

  • 1Department of Urology, Sahlgrenska University Hospital, Göteborg, Sweden. tomas.knutsson@sahlgrenska.se

Neurourology and Urodynamics
|June 1, 2001
PubMed
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Overactive bladder (OB) frequently coexists with bladder outlet obstruction (BOO) in men with benign prostatic hyperplasia (BPH). Increased obstruction severity correlates with a higher incidence of OB, suggesting BOO may contribute to OB development.

Area of Science:

  • Urology
  • Andrology
  • Nephrology

Background:

  • Benign prostatic hyperplasia (BPH) commonly causes lower urinary tract symptoms (LUTS) due to bladder outlet obstruction (BOO).
  • The coexistence of overactive bladder (OB) with BOO in BPH patients is not fully characterized.
  • Understanding this relationship is crucial for effective BPH management.

Purpose of the Study:

  • To systematically evaluate the prevalence of OB in men with BPH-induced BOO.
  • To differentiate characteristics between patients with pure BOO and those with combined BOO and OB (BOO + OB).

Main Methods:

  • A cohort of 162 men with LUTS due to BPH was prospectively studied.
  • Urodynamic assessments, including cystometry and pressure-flow studies, were performed.

Related Experiment Videos

  • Patients were categorized into pure BOO or BOO + OB groups based on urodynamic findings.

    • Main Results:

    • 45% of patients presented with combined BOO + OB, while 55% had pure BOO.
    • Patients with BOO + OB were older, had higher s-PSA levels, smaller voided volumes, and greater obstruction.
    • A strong positive association was observed between the degree of obstruction and the presence of OB.

    Conclusions:

    • Overactive bladder (OB) is a common comorbidity in men with benign prostatic hyperplasia (BPH)-induced bladder outlet obstruction (BOO).
    • The severity of BOO appears to be a significant factor in the development or exacerbation of OB.
    • BOO may be a progressive condition that contributes to the emergence of OB over time.