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Bladder Smooth Muscle Strip Contractility as a Method to Evaluate Lower Urinary Tract Pharmacology
Published on: August 18, 2014
Involuntary detrusor contractions: correlation of urodynamic data to clinical categories
L J Romanzi1, A Groutz, D M Heritz
1Weill Medical College, Cornell University, New York, New York, USA.
Neurourology and Urodynamics
|June 1, 2001
Summary
Involuntary detrusor contractions (IDC) are common in both neurologically intact and impaired patients with voiding symptoms. The ability to suppress IDC, not its characteristics, may predict treatment success.
Area of Science:
- Urology
- Neuro-urology
- Lower Urinary Tract Symptoms
Background:
- Limited data exists on involuntary detrusor contractions (IDC) prevalence and urodynamic features across different patient groups.
- Understanding these characteristics is crucial for diagnosing and managing lower urinary tract symptoms.
Purpose of the Study:
- To investigate if urodynamic characteristics of IDC differ across various clinical categories.
- To compare IDC in neurologically intact versus neurologically impaired patients with persistent irritative voiding symptoms.
Main Methods:
- Prospective enrollment of 111 neurologically intact and 21 neurologically impaired patients.
- Detailed clinical and urodynamic evaluation, categorizing patients into four groups based on symptoms and neurological status.
- Analysis of eight urodynamic characteristics of IDC, including pressure, perception, and ability to abort.
Main Results:
- IDC observed in 100% of neurologically impaired patients versus 76% of neurologically intact patients (P < 0.001).
- IDC occurred around 80% of cystometric capacity across all groups.
- Continent patients with frequency/urgency showed a higher ability to abort IDC (77%) compared to urge incontinent (46%) and neurogenic bladder patients (38%).
Conclusions:
- Urodynamic characteristics of IDC are not sufficiently distinct for differential diagnosis of detrusor overactivity.
- The ability to abort IDC and control incontinent flow has prognostic implications for treatment response, particularly behavioral therapies.
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