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Effects of magnetic resonance imaging on polymorphonuclear neutrophil adhesion
A Minczykowski1, W Paprzycki, J Smielecki
1Department of Cardiology and Intensive Therapy, Institute of Internal Medicine, Medical University, Przybyszewskiego 49, 60-355 Poznań, Poland.
Background:
Limited research has been performed concerning the effects of MR imaging on the immune system. In this study the influence of MR imaging exposure on polymorphonuclear neutrophil (PMN) adhesion was evaluated.
Material And Methods:
In vivo and in vitro studies were performed in 10 patients undergoing an MR imaging procedure, PMN adhesion to a plastic surface, as well as the expression of adhesion molecules beta 2-integrins CD11b, CD18, and L-selectin on the surface of PMN were estimated.
Results:
Exposure to MR imaging significantly increased adhesion of isolated PMNs to plastic surfaces. PMNs from blood samples obtained from patients undergoing MR imaging as well as from blood samples placed beside patients during MR imaging did not differ from controls in adhesion to plastic surfaces. Similarly, plasma from three tested samples did not change control PMN adhesion to plastic surface. Expression of beta 2-integrins (CD11, CD18) was significantly increased in samples left beside patients during MR imaging, while significantly decreased in samples obtained from patients after MR imaging exposure when compared to control samples. Expression of the surface adhesion molecule L-selectin on the surface of PMN decreased significantly in blood samples left beside patients during MR imaging.
Conclusion:
The results indicate that the PMN adhesion properties increase under the influence of MR imaging exposure. This phenomenon may be the result of direct stimulation of polymorphonuclear neutrophils by the exposure to MR imaging.
Insights
Magnetic Resonance (MR) imaging exposure increases polymorphonuclear neutrophil (PMN) adhesion. This suggests MR imaging may directly stimulate these immune cells, impacting their function.
Area of Science:
- Immunology
- Medical Imaging
Background:
- Limited research exists on Magnetic Resonance (MR) imaging's effects on the immune system.
- This study investigated MR imaging's influence on polymorphonuclear neutrophil (PMN) adhesion.
Purpose of the Study:
- To evaluate the impact of MR imaging exposure on PMN adhesion and adhesion molecule expression.
- To determine if MR imaging directly affects neutrophil function.
Main Methods:
- In vivo and in vitro studies were conducted on 10 patients undergoing MR imaging.
- Assessed PMN adhesion to plastic surfaces and expression of CD11b, CD18, and L-selectin.
- Compared samples from patients, adjacent samples, and controls.
Main Results:
- MR imaging exposure significantly increased isolated PMN adhesion to plastic.
- Beta 2-integrin expression increased in adjacent samples but decreased in patient samples post-exposure.
- L-selectin expression decreased significantly in adjacent samples.
Conclusions:
- MR imaging exposure enhances PMN adhesion properties.
- This effect may stem from direct stimulation of neutrophils by MR imaging.