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Related Experiment Videos

[Fibromyalgia].

D Pongratz1, M Späth

  • 1Friedrich-Baur-Institut, Medizinische und Neurologische Klinik, Klinikum der Universität, Innenstadt, München.

Fortschritte Der Neurologie-Psychiatrie
|June 2, 2001
PubMed
Summary
This summary is machine-generated.

Fibromyalgia diagnosis requires excluding other disorders and considering autonomic and mental factors. Its exact cause remains uncertain, though central hyperexcitability and biochemical changes are implicated.

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[Etiology and pathophysiology of fibromyalgia syndrome].

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[Fibromyalgia].

Zeitschrift fur Rheumatologie·2011
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Fibromyalgia syndrome: definition and diagnostic aspects.

Reumatismo·2009

Area of Science:

  • Rheumatology
  • Neurology
  • Pathophysiology

Context:

  • Fibromyalgia classification relies on American College of Rheumatology criteria.
  • Autonomic disturbances and mental features are crucial for diagnosis.
  • Distinguishing fibromyalgia from myofascial pain syndrome is essential.

Purpose:

  • To outline diagnostic criteria for fibromyalgia.
  • To discuss the differential diagnosis of fibromyalgia.
  • To review current understanding of fibromyalgia etiology and pathogenesis.

Summary:

  • Fibromyalgia diagnosis necessitates excluding internal and neurological disorders.
  • Myopathological findings in fibromyalgia are non-specific, including type-II-fiber atrophy and mitochondrial proliferation.

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  • Biochemical alterations involve the serotonin system and elevated substance P levels.

    • Impact:

    • Highlights the complexity of fibromyalgia diagnosis due to overlapping symptoms with other chronic pain disorders.
    • Underscores the need for further research into the uncertain etiology and pathogenesis of fibromyalgia.
    • Emphasizes the importance of considering central hyperexcitability in skeletal muscle pain conditions.