Pentanucleotide short tandem repeat locus DXYS156 displays different patterns of variations in human populations
1Institut fuer Rechtsmedizin, Universitaet Muenster, Von-Esmarch-Str. 62, D-48149 Münster, Germany. brinkma@uni-muenster.de
Aim:
To establish a database for the pentameric short tandem repeat locus DXYS156 from worldwide populations for routine genotyping in forensic identity testing and evolutionary biology.
Methods:
Using polymerase chain reaction with a newly designed primer pair, we analyzed 1,408 male and female samples from 28 populations representing four major geographic groups.
Results:
We observed 11 different alleles, which we sequenced and used to construct an allelic ladder.
Conclusion:
DXYS156 displays a contrasting pattern of X-linked and Y-linked variation among geographic regions, and between X and Y chromosomes. This complex allele distribution may be forensically useful for the ethnic differentiation of unknown stains.
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