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[Visceral candidiasis].

R Herbrecht1, A Zamfir, V Letscher-Bru

  • 1Département d'hématologie et d'oncologie Hôpital de Hautepierre 67098 Strasbourg. raoul.herbrecht@chru-strasbourg.fr

La Revue Du Praticien
|June 5, 2001
PubMed
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Invasive candidiasis, a common infection in immunocompromised patients, is often diagnosed via blood cultures. Treatment involves antifungals like fluconazole and Amphotericin B, with catheter removal crucial for candidemia.

Area of Science:

  • Infectious Diseases
  • Mycology
  • Critical Care Medicine

Background:

  • Invasive candidiasis is a significant opportunistic infection, particularly affecting immunocompromised individuals.
  • Key risk factors include neutropenia, broad-spectrum antibiotic use, Candida colonization, and central venous catheters.
  • Candidemia represents the most frequent clinical manifestation of invasive candidiasis.

Purpose of the Study:

  • To outline the diagnostic approaches for invasive candidiasis.
  • To discuss current prophylaxis and treatment strategies for invasive candidiasis.
  • To highlight the importance of risk factor management and timely intervention.

Main Methods:

  • Diagnosis relies on positive cultures from blood, skin biopsy, or deep-seated lesion aspiration.

Related Experiment Videos

  • Serological tests are generally not reliable in severely immunocompromised patients.
  • Treatment selection is guided by infection site, severity, fungal species, and patient's condition.

    • Main Results:

    • Antifungal drugs of choice include Amphotericin B (deoxycholate or lipid formulations) and fluconazole.
    • Strict hygiene and oral fluconazole are recommended for prophylaxis in neutropenic patients.
    • Removal of central venous catheters is a critical consideration in managing candidemia.

    Conclusions:

    • Prompt diagnosis and appropriate antifungal therapy are essential for managing invasive candidiasis.
    • Risk factor modification, including catheter removal, plays a vital role in patient outcomes.
    • Tailored treatment based on clinical context and causative species improves therapeutic efficacy.