Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Optokinetic reflex dysfunction in multiple sclerosis.

L Todd1, J King, C L Darlington

  • 1Department of Psychology and the Neuroscience Research Centre, University of Otago, Dunedin, New Zealand.

Neuroreport
|June 5, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cell proliferation in the cochlear nucleus following acoustic trauma in rat.

Neuroscience·2015
Same author

The effects of chronic tinnitus caused by acoustic trauma on social behaviour and anxiety in rats.

Neuroscience·2011
Same author

The effects of acoustic trauma that can cause tinnitus on spatial performance in rats.

Neuroscience·2011
Same author

Comparison of the effects of adrenocorticotropic hormone fragment 4-10 (ACTH(4-10)) and [D-Phe7]ACTH(4-10) on the compensation of spontaneous nystagmus in guinea pig.

Restorative neurology and neuroscience·2011
Same author

Acoustic trauma that can cause tinnitus impairs impulsive control but not performance accuracy in the 5-choice serial reaction time task in rats.

Neuroscience·2011
Same author

Potential involvement of NOS and arginase in age-related behavioural impairments.

Experimental gerontology·2004
Same journal

Electroacupuncture alleviates neuroinflammation and promotes recovery of neurological functions after intracerebral hemorrhage by modulating α7nAChR/JAK2/STAT3 signaling pathway.

Neuroreport·2026
Same journal

Non-cell-autonomous regulation of Bhlhb5 expression in cortical projection neurons by GABAergic interneuron development and position.

Neuroreport·2026
Same journal

C-C motif chemokine ligand 3 mediates inflammatory response via NLRP3 inflammasome and neuron damage after traumatic brain injury.

Neuroreport·2026
Same journal

Methyltransferase-like 14 alleviates neuronal ferroptosis in Alzheimer's disease by regulating the peroxiredoxin 6/apoptosis signal-regulating kinase 1 signaling pathway.

Neuroreport·2026
Same journal

Hand mental rotation reaction time reflects motor imagery strategy and predicts changes in finger dexterity after motor imagery.

Neuroreport·2026
Same journal

Functional exploration of metabotropic glycine receptors in cultured rat hippocampal slices.

Neuroreport·2026
See all related articles

Multiple sclerosis (MS) impairs optokinetic nystagmus (OKN) and optokinetic afternystagmus (OKAN) function. Specifically, MS patients showed reduced OKN slow phase velocity and OKAN time constant, indicating significant visual-vestibular system deficits.

Area of Science:

  • Neuroscience
  • Ophthalmology
  • Neurology

Background:

  • Optokinetic reflex (OKR) is crucial for visual-vestibular integration.
  • Multiple sclerosis (MS) is a demyelinating disease affecting the central nervous system, potentially impacting visual-vestibular pathways.

Purpose of the Study:

  • To investigate optokinetic reflex function in patients with multiple sclerosis.
  • To quantify specific parameters of optokinetic nystagmus (OKN) and optokinetic afternystagmus (OKAN) in MS.

Main Methods:

  • Electro-oculography (EOG) was used to measure gaze-holding, OKN, OKAN, and circularvection latency.
  • A rotating optokinetic drum served as the visual stimulus.
  • Comparison was made between a group of MS patients and a healthy control group.

Related Experiment Videos

Main Results:

  • Gaze-holding did not differ significantly between groups, but eccentric gaze-evoked nystagmus was observed in some MS patients.
  • No significant differences in OKN frequency or circularvection latency were found.
  • MS patients exhibited significantly reduced OKN slow phase velocity and OKAN time constant (p < 0.05 and p < 0.005, respectively).

Conclusions:

  • Optokinetic nystagmus and optokinetic afternystagmus are significantly impaired in multiple sclerosis.
  • These findings highlight deficits in the visual-vestibular system in MS patients.
  • OKR testing may serve as a valuable tool for assessing neurological function in MS.