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Related Experiment Videos

Mouse model for morningness/eveningness.

H Sei1, K Oishi, Y Morita

  • 1Department of Physiology, School of Medicine, The University of Tokushima, Japan.

Neuroreport
|June 5, 2001
PubMed
Summary
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This study investigated the Clock gene mutation in mice, revealing a two-hour delay in circadian rhythms. This finding supports the link between the molecular circadian clock and human morning/evening preferences, suggesting a valuable animal model.

Area of Science:

  • Chronobiology
  • Molecular genetics
  • Animal models

Background:

  • Human morning/evening preferences are linked to the Clock gene's 3' flanking region polymorphism.
  • The Clock gene is the first identified mammalian circadian clock gene.

Purpose of the Study:

  • To investigate the effect of Clock gene mutation on circadian rhythms in mice.
  • To establish a mouse model for human morning/evening preference.

Main Methods:

  • Recorded body temperature, spontaneous activity, electroencephalogram (EEG), and electromyogram (EMG) for 48 hours in wild-type and Clock-mutant (Cl/Cl) mice.
  • Utilized Jcl:ICR genetic background mice.

Main Results:

  • Both wild-type and Cl/Cl mice exhibited complete entrainment of body temperature, activity, wake, and sleep to the light-dark (LD) cycle.

Related Experiment Videos

  • Cl/Cl mice showed a phase delay of approximately 2 hours in body temperature, activity, and wake duration rhythms compared to wild-type mice.

    • Conclusions:

    • The study provides further evidence for a close relationship between human morning/evening preference and the molecular circadian clock system.
    • Clock-mutant mice (Cl/Cl on Jcl:ICR) are a useful animal model for studying human morning/evening preference.