Meta-analysis for epidemiologic studies on the relationship between smoking and Parkinson's disease
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Updated: Oct 7, 2026

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
Published on: January 7, 2014
M Sugita1, T Izuno, M Tatemichi
1Department of Environmental and Occupational Health, Toho University School of Medicine, Tokyo, Japan.
Abstract:
Many epidemiologic studies on the relationship between smoking and Parkinson's disease (PD) have been conducted. Morens et al. reviewed many articles in the study field and concluded that smoking is inversely associated with the risk of PD. In the present study, the object is to obtain summarized risk estimates of the relationship from the published articles using meta-analysis. Summarized risk estimates on the relationship between smoking and PD were found to be about 0.5 with statistical significance in meta-analysis. Therefore, the result that smoking is inversely associated with the risk of PD is appropriate.
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