Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Imaging infection with LeuTech.

M L Thakur1, C S Marcus, S L Kipper

  • 1Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, USA. Mathew.Thakur@mail.tju.edu

Nuclear Medicine Communications
|June 5, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The European Rare Disease Network for HHT Frameworks for management of hereditary haemorrhagic telangiectasia in general and speciality care.

European journal of medical genetics·2021
Same author

Safety and immunogenicity of two formulations of rotavirus vaccine in Vietnamese infants.

Vaccine·2021
Same author

Development of gynecomastia following initiation of bictegravir/emtricitabine/tenofovir alafenamide.

International journal of STD & AIDS·2020
Same author

Diffusion tensor imaging reveals changes in microstructural integrity along compressed nerve roots that correlate with chronic pain symptoms and motor deficiencies in elderly stenosis patients.

NeuroImage. Clinical·2019
Same author

Relationships between the integrity and function of lumbar nerve roots as assessed by diffusion tensor imaging and neurophysiology.

Neuroradiology·2017
Same author

Novel strategies for targeting innate immune responses to influenza.

Mucosal immunology·2016
Same journal

Diagnostic performance and quantitative characterization of PET/computed tomography in peritoneal deposits assessment.

Nuclear medicine communications·2026
Same journal

Diagnostic value of dual-time-point 18F-fluorodeoxyglucose PET/computed tomography in differentiating benign and malignant extrahepatic bile duct occupying lesions.

Nuclear medicine communications·2026
Same journal

Prognostic value of baseline 18F- fluroodexoygloucose PET/computed tomography-derived maximum standardized uptake value and tumor bulk in pediatric Hodgkin lymphoma: a retrospective analysis.

Nuclear medicine communications·2026
Same journal

A comparative assessment of [99mTc] HYNIC-PSMA-11 scintigraphy in prostate cancer as a potential substitute for disease evaluation with [68Ga] PSMA-11 PET/CT imaging.

Nuclear medicine communications·2026
Same journal

Prediction of tumor radiation absorbed dose in radionuclide therapy based on the mean standardized uptake value from PET imaging.

Nuclear medicine communications·2026
Same journal

Serum cytokine profiles in papillary thyroid carcinoma patients with lung metastases: characteristics and the relationship with prognosis.

Nuclear medicine communications·2026
See all related articles

LeuTech, a technetium-99m labeled antibody, effectively images infections with high accuracy. This diagnostic agent shows promise for rapid detection of infectious foci with no observed adverse effects.

Area of Science:

  • Nuclear Medicine
  • Immunology
  • Infectious Disease Diagnostics

Background:

  • CD15 receptors are highly expressed on human neutrophils.
  • Monoclonal antibodies can be targeted to specific cellular markers for diagnostic imaging.

Purpose of the Study:

  • To evaluate the efficacy of LeuTech, a 99mTc-labeled anti-CD15 monoclonal antibody, for imaging infection.
  • To assess the Human Anti-Mouse Antibody (HAMA) response to LeuTech.

Main Methods:

  • 46 patients with suspected infections received intravenous injections of LeuTech.
  • Infection imaging was performed, and results were compared to clinical outcomes.
  • 30 healthy volunteers were monitored for HAMA response after LeuTech administration.

Related Experiment Videos

Main Results:

  • LeuTech demonstrated high accuracy (96%), sensitivity (95%), and specificity (100%) in detecting infectious foci.
  • 92% of positive scans were identified within 10 minutes post-injection.
  • No significant HAMA response or adverse reactions were observed in patients or volunteers.

Conclusions:

  • LeuTech is a highly effective and safe agent for the rapid imaging of infectious foci.
  • Its high affinity for CD15 receptors on neutrophils contributes to its diagnostic utility.
  • LeuTech shows significant potential for improving the speed and accuracy of infection diagnosis.