Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Model systems for flavoenzyme activity. Control of flavin recognition via specific electrostatic interactions.

A J Goodman1, E C Breinlinger, C M McIntosh

  • 1Department of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, USA.

Organic Letters
|June 5, 2001
PubMed
Summary

Aromatic molecule orientation dictates how flavin molecules interact and change their redox state. This study reveals dipole orientation is key for molecular recognition and flavin behavior.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Past progress in environmental nanoanalysis and a future trajectory for atomic mass-spectrometry methods.

NanoImpact·2024
Same author

Nanoparticle probes for quantifying supramolecular determinants of biosurface affinity.

Particle & particle systems characterization : measurement and description of particle properties and behavior in powders and other disperse systems·2018
Same author

Delivery approaches for CRISPR/Cas9 therapeutics in vivo: advances and challenges.

Expert opinion on drug delivery·2018
Same author

Challenges in Application of Langmuir Monolayer Studies To Determine the Mechanisms of Bactericidal Activity of Ruthenium Complexes.

Langmuir : the ACS journal of surfaces and colloids·2017
Same author

Preparation of Biocatalytic Microparticles by Interfacial Self-Assembly of Enzyme-Nanoparticle Conjugates Around a Cross-Linkable Core.

Methods in enzymology·2016
Same author

Goodman and Tisdale Reply.

Physical review letters·2016

Area of Science:

  • Biochemistry
  • Computational Chemistry
  • Molecular Recognition

Background:

  • Flavin cofactors are essential in numerous biological redox reactions.
  • Understanding molecular interactions is crucial for designing enzyme mimics and therapeutics.
  • Aromatic systems play vital roles in biological recognition processes.

Purpose of the Study:

  • To investigate the influence of dipole orientation in aromatic systems on flavin interactions.
  • To elucidate the role of host dipole orientation in determining flavin guest recognition and redox behavior.
  • To establish a model system for studying host-guest molecular interactions.

Main Methods:

  • Utilized a model system to examine host-guest interactions.
  • Performed ab initio computational studies.

Related Experiment Videos

  • Conducted experimental investigations.

    • Main Results:

    • Dipole orientation within the host molecule significantly impacts flavin recognition.
    • Host dipole orientation is a critical determinant of flavin guest's redox behavior.
    • The model system successfully demonstrated the importance of specific molecular orientations.

    Conclusions:

    • Molecular dipole orientation is a key factor in flavin-aromatic system interactions.
    • Precise control of dipole orientation can modulate flavin redox activity.
    • This research provides insights into molecular recognition mechanisms relevant to flavin-dependent processes.