Related Experiment Video
Updated: Aug 4, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
Published on: November 4, 2010
Short-term outcomes after acute treatment of pediatric asthma
1Department of Pediatrics, Division of Emergency Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. msteve@chmc.org
Insights
Pediatric asthma patients treated in the emergency department (ED) experience significant short-term illness, including persistent symptoms and functional disability. Standard ED success markers like avoiding hospital admission do not fully capture the recovery of children with acute asthma.
Area of Science:
- Pediatric Emergency Medicine
- Respiratory Medicine
- Public Health
Background:
- Short-term outcomes for pediatric asthma patients post-emergency department (ED) treatment are under-documented.
- Previous studies focused narrowly on ED length of stay, hospital admission, and relapse rates.
Purpose of the Study:
- To comprehensively assess symptom persistence, medication use, functional disability, and follow-up in children after acute asthma treatment and ED discharge.
- To evaluate relapse rates and patient-oriented outcomes within two weeks of ED care.
Main Methods:
- Prospective cohort study of pediatric asthma patients treated in an inner-city hospital ED.
- Telephone interviews conducted at 1 and 2 weeks post-discharge for 367 patients.
- Data collected on symptom duration, activity levels, school/work absenteeism, medication use, and follow-up care.
Main Results:
- Significant morbidity observed: 23% had persistent cough, 12% wheezing at 2 weeks.
- 20% experienced decreased activity, and substantial school/daycare (45%) and work absenteeism (54%) occurred.
- 32% used increased medication, relapse rate was 13%, and routine follow-up was poor (48% had no visit planned).
Conclusions:
- Inner-city pediatric asthma patients discharged from the ED often have poor short-term outcomes.
- Traditional markers like hospital admission and relapse do not fully represent the impact of acute asthma care.
- Patient-centered outcomes, including symptom persistence and functional disability, offer a more accurate evaluation of ED treatment effectiveness.
Context:
The short-term course of pediatric patients after emergency department (ED) treatment for acute asthma has not been comprehensively documented; most previous studies have limited outcomes to ED length-of-stay, hospital admission, and relapse.
Objective:
To describe symptom persistence, medication use, functional disability, follow-up, and relapse in these children in the 2 weeks after acute treatment and ED discharge.
Design:
Randomly selected, prospective cohort from September 1996 to August 1997; follow-up telephone interviews at 1 and 2 weeks. Setting. A large, inner-city children's hospital emergency department. Patients. Random sample of pediatric asthma visits requiring ED treatment but not admission; 457 were eligible, 388 with complete follow-up (85%); final sample included 367 patients after multiple visits deleted.
Main Outcome Measures:
Details of symptom persistence, functional disability, medication use, relapse, and routine follow-up.
Results:
Results included significant morbidity: 23% (95% confidence interval [CI]: 19, 27) with cough and 12% (95% CI: 9, 15) with wheeze persistent at 2 weeks; 20% (95% CI: 16, 24) with decreased activity at 1 week; 45% (95% CI: 39, 51) missed >2 and 24% (95% CI: 19, 29) >/=5 days of school or day care; 17% (95% CI: 13, 21) spent >/=3 days in bed; 54% (95% CI: 47, 60) of caretakers missed at least 1 and 18% (95% CI: 13, 24) missed >2 days of school or work; and 32% (95% CI: 28, 38) of patients were still using greater than baseline medication at 2 weeks. Reported relapse rates were averaged at 13% (95% CI: 10, 17) with 3% (95% CI: 1, 5) admitted. Routine office follow-up was poor: 29% (95% CI: 25, 34) had had a visit; 48% (95% CI: 43, 54) reported no visit/none planned.
Conclusions:
A considerable proportion of inner-city pediatric patients discharged from the hospital from the ED after standard treatment for acute asthma had poor short-term outcomes. Conventional markers of successful ED treatment, such as avoiding hospital admission or relapse, do not adequately describe outcomes of acute care. The patient-oriented measures described here may provide more useful indicators of outcome in the evaluation of acute asthma care.
Related Concept Videos
Antiasthma Drugs: β2-Adrenoceptor Agonists
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce relaxation in these...
Antiasthma Drugs: Leukotriene Modifiers
Leukotriene modifiers work through two distinct mechanisms:
Acute Respiratory Failure-V
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Asthma-III: Symptoms and Complications
Classification of Asthma
Asthma-IV: Diagnostic and Management
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Asthma III: Clinical Manifestations