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Positron emission mammography-guided breast biopsy
R R Raylman1, S Majewski, A G Weisenberger
1Center for Advanced Imaging, Department of Radiology, West Virginia University, Morgantown, West Virginia 26506-9236, USA.
Summary
This study introduces a new method for performing stereotactic breast biopsies guided by Positron Emission Mammography (PEM). The technique accurately guides biopsies for potentially cancerous breast lesions detected with PEM.
Area of Science:
- Medical Imaging
- Oncology
- Radiology
Background:
- Positron Emission Mammography (PEM) detects radiotracer-avid breast tumors.
- Minimally invasive biopsies improve diagnostic accuracy for PEM-detected lesions.
Purpose of the Study:
- To evaluate a novel method for performing stereotactic breast biopsies guided by PEM.
Main Methods:
- A PEM system with scintillator crystal arrays was used on a stereotactic biopsy table.
- A new trigonometric algorithm and +/-15 degree imaging were employed for guidance.
- Accuracy was tested using point sources of (18)F; simulated biopsies were performed on a breast phantom with (18)F-FDG.
Main Results:
- Point source positions were calculated within 0.6 mm of true locations (mean error +/-0.4 mm).
- Simulated biopsies successfully acquired samples from target lesions in all 5 trials.
- Needle positioning verification methods were also tested.
Conclusions:
- The developed technique shows potential for guiding biopsies of PEM-detected breast lesions.
- This method can enhance the diagnostic accuracy of Positron Emission Mammography.