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From Genetically Altered Mice to Integrative Physiology.

Max Gassmann1, Thierry Hennet

  • 1Institute of Physiology, University of Zürich-Irchel, CH-8057 Zürich, Switzerland.

News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society
|June 8, 2001
PubMed
Summary

Genetically engineered mice, including transgenic and gene-targeted models, are powerful tools for studying gene function in whole organisms. This review highlights their utility in connecting molecular biology with integrative physiology research.

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Area of Science:

  • Physiology
  • Molecular Biology
  • Genetics

Background:

  • Transgenic and gene-targeted mice enable the study of individual gene functions within a complete biological system.
  • These genetically modified organisms bridge the gap between molecular mechanisms and whole-organism physiology.

Purpose of the Study:

  • To review the physiological insights gained from using genetically engineered mouse models.
  • To demonstrate the potential of transgenic mice in advancing integrative physiology.

Main Methods:

  • Utilizing transgenic mouse models.
  • Employing gene-targeting techniques in mice.
  • Reviewing existing literature on genetically engineered mice.

Main Results:

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  • Genetically engineered mice provide crucial data on gene function.
  • These models facilitate the understanding of complex physiological processes.
  • Physiologically relevant information has been obtained through these models.

Conclusions:

  • Transgenic and gene-targeted mice are invaluable for studying gene function.
  • Genetically engineered mice significantly contribute to integrative physiology.
  • The application of these models offers a powerful approach to biological research.