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Ethanol: Novel Actions on Nerve Cell Physiology Explain Impaired Functions
Esa R. Korpi1, Riikka Mäkelä, Mikko Uusi-Oukari
1Department of Pharmacology and Clinical Pharmacology, University of Turku, FIN-20520 Turku, Finland.
Abstract:
Molecular biological tools have revealed receptor proteins for excitatory and inhibitory neurotransmitters on cell membranes as targets of ethanol action. Behavioral and pharmacogenetic assays using rodent lines have supported this neurotransmitter theory of ethanol action and given a firm basis for future identification of the relevant genes and the central physiological processes vulnerable to ethanol.