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Unraveling the Mystery of Goldblatt Hypertension
L. Gabriel Navar1, Lixian Zou, Annette Von Thun
1Dept. of Physiology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Abstract:
In hypertension caused by unilateral renal artery stenosis, the nonstenotic kidney becomes renin depleted but fails to prevent hypertension. The nonstenotic kidney mysteriously develops elevated intrarenal angiotensin II (ANG II) content. Rats chronically infused with ANG II exhibit a similar hypertensive process. The augmentation of intrarenal ANG II is due to receptor-mediated internalization and continued ANG II formation, which provide a hypertensinogenic stimulus.
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