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Proteinase-Activated Receptors: New Functions for Old Enzymes
Stephan K. Böhm1, Karen McConalogue, Wuyi Kong
1Dept. of Surgery, University of California San Francisco, San Francisco, CA 94143-0660, USA.
Abstract:
Although proteases are traditionally viewed as degradative enzymes, characterization of a family of G protein-coupled receptors that are activated by proteolysis reveals a new role. Certain proteases function as signaling molecules that specifically regulate cells by cleaving and activating a family of proteinase-activated receptors.