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Understanding the Physiology of the Blood-Brain Barrier: In Vitro Models
Gerald A. Grant1, N. Joan Abbott, Damir Janigro
1Department of Neurological Surgery, University of Washington School of Medicine, 325 9th Ave., Seattle, WA 98104, USA.
Abstract:
Endothelial cells exposed to inductive central nervous system factors differentiate into a blood-brain barrier phenotype. The blood-brain barrier frequently obstructs the passage of chemotherapeutics into the brain. Tissue culture systems have been developed to reproduce key properties of the intact blood-brain barrier and to allow for testing of mechanisms of transendothelial drug permeation.