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Molecular Features of Energy Coupling in the F(0)F(1) ATP Synthase
1Department of Molecular Physiology and Biological Physics at the University of Virginia, PO Box 10011, Charlottesville, VA 22906-0011, USA.
Abstract:
H(+) translocation is coupled to ATP synthesis in the F(0)F(1) ATP synthase via a rotary mechanism. Catalytic turnover, site-site cooperativity, and H(+) transport obligatorily involve rotation of a set of subunits. The transport domain in the membranous F(0) and the catalytic domain in the F(1) are mechanisms designed for generating torque.