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Atrial Natriuretic Peptide: Regulator of Chronic Arterial Blood Pressure
Luis Gabriel Melo1, Stephen C. Pang, Uwe Ackermann
1Department of Physiology of the University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada.
Abstract:
Recent findings in atrial natriuretic peptide (ANP) transgenic and gene knockout mouse models uncovered a tonic vasodilatory effect of this hormone that contributes to chronic blood pressure homeostasis. With elevated salt intake, ANP-mediated antagonism of the renin-angiotensin system is essential for blood pressure constancy, suggesting that a deficiency in ANP activity may underlie the etiology of sodium-retaining disorders.