Toward Understanding the Role of Methylation in Aldosterone-Sensitive Na(+) Transport

Proper endocrine regulation of Na(+) reabsorption by renal principal cells is the primary means in mammals for maintaining blood pressure. Aldosterone increases Na(+) reabsorption by activating luminal Na(+) channels; however, the signal transduction pathway of aldosterone is not fully understood. Cellular methylation is necessary for aldosterone signaling to the luminal Na(+) channel. We describe the enzymes, regulators, and effectors of aldosterone-mediated methylation relevant to Na(+) reabsorption.