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Ca(2+)-Activated Cl(-) Channels: A Newly Emerging Anion Transport Family
Catherine M. Fuller1, Dale J. Benos
1Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, Alabama 35294.
Abstract:
A new family of Cl(-) channels widely expressed in epithelia has been identified. These proteins are associated with Ca(2+)-sensitive conductive Cl(-) transport when heterologously expressed. This family may underlie the Ca(2+)-mediated Cl(-) conductance responsible for rescue of the cystic fibrosis knockout mouse from significant airway disease.