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UTP as an extracellular signaling molecule
1School of Medicine, Department of Medicine, The Cystic Fibrosis Treatment and Research Center, University of North Carolina, Chapel Hill, NC 27599-7248, USA.
Abstract:
In addition to their central role in many biochemical processes, uridine nucleotides are important extracellular signaling molecules that regulate a broad spectrum of cell functions via activation of P2Y2, P2Y4, and P2Y6 receptors. Cellular release of UTP provides a mechanism for autocrine control of calcium- or protein kinase C-dependent processes.