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Updated: Aug 11, 2026

Spatio-Temporal Manipulation of Small GTPase Activity at Subcellular Level and on Timescale of Seconds in Living Cells
Published on: March 9, 2012
Traffic control: Rab GTPases and the regulation of interorganellar transport
M J Tuvim1, R Adachi, S Hoffenberg
1Department of Medicine, Baylor College of Medicine and Houston VA Medical Center, 2002 Holcombe Blvd., Houston TX 77030, USA.
Abstract:
Membrane proteins, membrane lipids, and luminal contents are exchanged among the intracellular compartments of eukaryotic cells by vesicular transport. This process must be highly ordered to maintain cellular architecture in the face of rapid membrane turnover. The Ras-related Rab GTPases play multiple roles in regulating this traffic.
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