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Hepatic hemangioendothelioma associated with production of humoral thyrotropin-like factor
R M Ayling1, M Davenport, N Hadzic
1Department of Clinical Biochemistry, King's College Hospital, Denmark Hill, London SE5 9RS, United Kingdom.
The Journal of Pediatrics
|June 8, 2001
Abstract:
We report on 7 patients referred for treatment of hepatic hemangioendothelioma with increased thyrotropin levels. The serum thyroxine level was decreased in 4 and increased in 2. Immunohistochemistry showed positive staining of tumor, but not of normal liver tissue, for thyrotropin. We propose secretion by the tumor of a thyrotropin-like factor.