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[Reversed C.P.C.: Aggressive NK-cell leukemia/lymphoma].
1Graduate School of Allied Health Sciences, Tokyo Medical and Dental University.
Rinsho Byori. the Japanese Journal of Clinical Pathology
|June 8, 2001
Summary
Acute natural killer (NK)-cell leukemia is a rare, aggressive blood cancer. This case highlights a severe presentation with nasal and bone marrow involvement, leading to fatal multiorgan failure.
Area of Science:
- Hematology
- Oncology
- Immunology
Background:
- Granular lymphocyte-proliferative disorders (GLPD) are typically benign.
- Acute natural killer (NK)-cell leukemia/lymphoma is an aggressive malignancy.
Observation:
- A rare case of acute NK-cell leukemia presented with extranodal (nasal) and bone marrow infiltration.
- The neoplastic cells exhibited large granular lymphocyte morphology with a CD3-CD16-CD56+ immunophenotype.
Findings:
- The patient's condition rapidly deteriorated, becoming refractory to treatment.
- Death resulted from multiorgan failure, complicated by intravascular coagulation syndrome.
Implications:
- This case underscores the aggressive nature of acute NK-cell leukemia.
- Highlights the importance of recognizing specific immunophenotypes for diagnosis and prognosis.
- Emphasizes the critical role of prompt management in severe cases of NK-cell leukemia.