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[Review of thyroid disease and recent progress in thyroid research]
1Department of Clinical Laboratory Medicine, Dokkyo University School of Medicine, Mibu, Tochigi 321-0293.
Rinsho Byori. the Japanese Journal of Clinical Pathology
|June 8, 2001
Summary
This study reviews thyroid diseases, finding Graves' disease, Hashimoto's thyroiditis, and benign tumors are common. Genetic analysis suggests specific amino acids are crucial for thyroid hormone synthesis and thyroglobulin structure.
Area of Science:
- Endocrinology and Metabolism
- Genetics
- Molecular Biology
Context:
- A 26-year retrospective analysis of 19,944 patients revealed 22.4% had thyroid diseases.
- Graves' disease (37.3%), Hashimoto's thyroiditis (24.1%), and benign thyroid tumors (22.2%) were the most prevalent conditions.
- Significant gender disparity observed in Graves' disease (1:3.2 male-to-female ratio).
Purpose:
- To review major thyroid diseases and recent advancements in thyroid research.
- To present clinical experiences and genetic analysis data related to thyroid disorders.
- To investigate the role of specific amino acids in thyroglobulin structure and thyroid hormone synthesis.
Summary:
- Retrospective analysis identified key thyroid disease prevalences and demographic data.
- Genetic analysis highlighted the importance of surface electric charge-involved amino acids in thyroglobulin (Tg) structure and thyroid hormone synthesis.
- Long-term case studies emphasized the necessity of comprehensive, ongoing patient care for thyroid disease management, even with clinical improvement.
Impact:
- Provides insights into the prevalence and characteristics of common thyroid diseases.
- Identifies critical amino acid roles in thyroid function, potentially guiding future research.
- Underscores the importance of continuous, holistic patient management in endocrinology.