Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Thyroid function tests].

H Uchimura1

  • 1Department of Clinical Pathology, Kyorin University School of Medicine, Kyorin University, Mitaka 181-8611.

Rinsho Byori. the Japanese Journal of Clinical Pathology
|June 8, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Algorithm for the treatment of schizophrenia in Japan.

International journal of psychiatry in clinical practice·2014
Same author

Cerebral blood flow in nondemented elderly subjects with extensive deep white matter lesions on magnetic resonance imaging.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2013
Same author

Effect of the neurotoxic dose of methamphetamine on gene expression of parkin and Pael-receptors in rat striatum.

Parkinsonism & related disorders·2003
Same author

Quantitative MRI findings and cognitive impairment among community dwelling elderly subjects.

Journal of neurology, neurosurgery, and psychiatry·2002
Same author

Heterogeneity found in the cagA gene of Helicobacter pylori from Japanese and non-Japanese isolates.

Journal of gastroenterology·2001
Same author

DNA fragmentation in ischemic core and penumbra in focal cerebral ischemia in rats.

Brain research. Molecular brain research·2001

Diagnosing thyroid diseases like Hashimoto's and Graves' involves measuring thyroid function via TSH and FT4 hormones, and detecting autoantibodies. TSH is the primary indicator, with FT4 as a secondary assessment for thyroid health.

Area of Science:

  • Endocrinology
  • Immunology
  • Clinical Diagnostics

Context:

  • Autoimmune thyroid diseases, including Hashimoto's and Graves' disease, account for approximately 80% of all thyroid conditions.
  • Accurate diagnosis of thyroid disorders necessitates evaluating both thyroid function and the presence of pathogenetic autoantibodies.

Purpose:

  • To outline the essential diagnostic tests for thyroid diseases, focusing on thyroid function and autoantibody detection.
  • To highlight the significance of serum TSH concentrations as the primary and most informative measure of thyroid function.

Summary:

  • Thyroid function is assessed using serum hormone levels, with TSH (thyroid-stimulating hormone) being the most reliable indicator of hyperthyroid, euthyroid, or hypothyroid states. Reference intervals for TSH are typically 0.4-5.0 microU/ml.

Related Experiment Videos

  • FT4 (free thyroxine) is a preferred secondary test over total T4 due to its independence from binding protein variations. FT3 (free triiodothyronine) offers limited additional diagnostic value compared to T3.
  • Detection of thyroid autoantibodies, such as TgAb and TPOAb, is crucial. TSH receptor antibodies (TRAb, TSAb) are particularly important for differentiating Graves' disease from Hashimoto's thyroiditis and managing hyperthyroidism and certain hypothyroid cases.

    • Impact:

    • Establishes TSH measurement as the initial diagnostic step for thyroid function assessment.
    • Clarifies the roles of FT4 and FT3 in thyroid function testing, emphasizing FT4's superiority over TT4.
    • Underscores the diagnostic and prognostic value of TSH receptor antibodies in autoimmune thyroid diseases like Graves' disease.