Related Experiment Video
Updated: Aug 19, 2026

An Isolated Retinal Preparation to Record Light Response from Genetically Labeled Retinal Ganglion Cells
Published on: January 26, 2011
[Ionic currents responsible for activation of isolated retinal ganglion cells]
N M Veselovs'ka1, M S Veselovs'kyĭ
1Kiev Center of Eye Pathology, Kiev.
Abstract:
Ionic currents responsible for excitability of retinal ganglion cells (RGC) freshly isolated from eyes of adult rats were studied. Kutward potassium currents in RGC represented by populations of slow inactivating and non-inactivating currents. Inward sodium currents were completely blocked by extracellular application of 0.25 mM TTX. Calcium conductance in freshly isolated RGC has two components: low- and high-threshold. Extracellular application of nifedipine (10 mM) or Cd2+ (10 mM) blocked high threshold calcium currents by 28% and 60%, correspondingly, without any significant effect on low threshold calcium currents.
Related Concept Videos
The Retina
G-Protein Gated Ion Channels
Sensory organs,...
Anatomy of the Eyeball
Photoreceptors and Visual Pathways

