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[Evaluation of thyroid structure and function in patients with Turner syndromes]
K Łacka1, M Wawrzyniak, J Andrzejewska
1Klinika Endokrynologii IChW AM im. K. Marcinkowskiego w Poznaniu.
Polskie Archiwum Medycyny Wewnetrznej
|June 8, 2001
Summary
Patients with Turner syndrome have a higher incidence of thyroid disease, including hypothyroidism and Graves
Area of Science:
- Endocrinology
- Genetics
- Reproductive Health
Background:
- Turner syndrome is a genetic condition affecting females, often associated with various health issues.
- Thyroid dysfunction is a known complication, but comprehensive evaluations are essential.
Purpose of the Study:
- To assess thyroid structure and function in women with Turner syndrome.
- To compare thyroid parameters between Turner syndrome patients and healthy controls.
Main Methods:
- Cytogenetic examination
- Thyroid ultrasonography
- Serum thyroid hormone levels (total and free)
- Thyroid Stimulating Hormone (TSH)
- Thyroglobulin (Tg)
- Thyroid Hormone Binding Globulin (TBG)
- Antithyroglobulin (anti-Tg) and antithyroperoxidase (anti-TPO) antibodies
Main Results:
- Significantly lower ultrasonographic thyroid volume in Turner syndrome patients (11.03 cm3) compared to controls (16.98 cm3).
- Thyroid function abnormalities found in 22% of Turner syndrome cases: subclinical hypothyroidism (16%), overt hypothyroidism (3%), and hyperthyroidism (Graves' disease, 3%).
- Elevated antithyroid antibodies detected in 62% of Turner syndrome patients, significantly higher than controls (16%).
Conclusions:
- Thyroid diseases are more prevalent in Turner syndrome than in the general female population.
- Routine thyroid structure and function diagnostics are crucial for all Turner syndrome patients.
- Early detection and management of thyroid disorders are vital for improving health outcomes in Turner syndrome.