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A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
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A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors

Published on: December 7, 2014

Screening for c-mpl mutations in patients with congenital amegakaryocytic thrombocytopenia identifies a polymorphism

S van den Oudenrijn, M de Haas, A E von dem Borne

    Blood
    |June 8, 2001
    PubMed
    Abstract

    No abstract available in PubMed .

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    Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
    Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...

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