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Children with difficult asthma: a practical approach.

D N Payne1, I M Balfour-Lynn

  • 1Department of Paediatric Respiratory Medicine, Royal Brompton and Harefield NHS Trust, London, UK.

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
|June 8, 2001
PubMed
Summary
This summary is machine-generated.

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Children with difficult asthma benefit from intensive clinical trial management, regardless of medication. Optimizing asthma control requires careful diagnosis, adherence support, and identifying triggers for better treatment strategies.

Area of Science:

  • Pediatric Pulmonology
  • Clinical Trial Design
  • Asthma Pathophysiology

Background:

  • Many open studies show benefits from innovative asthma treatments.
  • Placebo groups in trials also show improvements, suggesting high patient support is key.

Purpose of the Study:

  • To investigate the benefits of intensive management in children with difficult asthma.
  • To highlight the need for understanding severe asthma subtypes for targeted therapies.

Main Methods:

  • Review of open and placebo-controlled trials for steroid-dependent asthma.
  • Analysis of factors contributing to asthma control in clinical trial settings.

Main Results:

  • Children with difficult asthma improve with intensive input, irrespective of specific medication.

Related Experiment Videos

  • Intensive management, focusing on diagnosis and adherence, is crucial for asthma control.

    • Conclusions:

    • High-input clinical trial management benefits children with difficult asthma.
    • Further research into severe asthma subtypes is needed for personalized, steroid-sparing treatments.