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Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
Published on: September 21, 2017
Liver cell specific targeting of peptide nucleic acid oligomers
X Zhang1, C G Simmons, D R Corey
1Department of Pharmacology and Biochemistry, University of Texas Southwestern Medical Center at Dallas, 75390-9041, USA.
Bioorganic & Medicinal Chemistry Letters
|June 8, 2001
Abstract:
Chimeric molecules consisting of peptide nucleic acid (PNA) and lactose have been synthesized to test the hypothesis that lactose moieties can promote cell-specific uptake of PNAs. We find that lactose modified PNAs rapidly enter liver-derived HepG2 cells while unmodified PNAs do not and that lactose modified PNAs can inhibit cellular telomerase.
